ENDAM – AA
Research type
Research Study
Full title
Evaluation of non-diameter aortic measurements for aortic aneurysm
IRAS ID
362892
Contact name
Marjan Jahangiri
Contact email
Sponsor organisation
City St George's University of London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Thoracic aortic aneurysms (TAAs) are life-threatening conditions which involve the dilation of the aorta, which if left untreated leads to rupture. Traditionally, they are assessed via the maximum aortic diameter. This has limitations in predicting rupture risk.
This project evaluates the clinical utility of non-diameter aortic measurements, such as cross-sectional area, height ratio, aortic diameters indexed to the patient height and weight. The intended benefit of this is for improved TAA risk stratification and management.
Using retrospective imaging data (CT/MRI/Echocardiogram) from TAA patients, image analysis and measurements will quantify these parameters and correlate them with clinical outcomes (surgery and postoperative surveillance imaging).
Statistical analysis will be employed in order to compare the predictive accuracy of the non-diameter metrics of the aorta against traditional diameter-based criteria.
In conclusion, this study aims to identify more reliable parameters for TAA progression, to support individualised surveillance and timely intervention. The results of this study could refine guidelines by utilising different parameters for assessing the aorta, thereby optimising patient outcomes.
REC name
London - Fulham Research Ethics Committee
REC reference
25/PR/1586
Date of REC Opinion
24 Nov 2025
REC opinion
Favourable Opinion