EMPIRIC Study
Research type
Research Study
Full title
Molecular profiling in colorectal cancer
IRAS ID
208327
Contact name
Nirupa Murugaesu
Contact email
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
Lay summary:
The EMPIRIC Study aims to enhance genetic testing provided to patients with colorectal cancer at St George’s Hospital.Need for study:
Over 40,000 patients were diagnosed with colorectal cancer in the United Kingdom in 2013, making it the second most common cause of cancer death in the UK (www.cancerresearchuk.org/health-professional/cancer-statistics). With the advent of bowel screening and greater health awareness, numbers diagnosed continue to increase. A greater understanding of this potentially devastating disease is required to optimise its management and improve cure rates.Aim of the project:
The primary aim is to validate a molecular panel that looks closely at 50 genes linked to an increase risk of developing cancer for use in routine care. We also aim to look at whether tumour DNA can be detected in the blood at different points of the disease.Patient benefit:
We know that cancer is a genetic disease and improving our understanding of the molecular profile of colorectal cancer may provide answers to why some patients respond to treatments and others don’t and help clinicians guide selection of second and third line chemotherapy treatments.REC name
South Central - Hampshire A Research Ethics Committee
REC reference
16/SC/0592
Date of REC Opinion
3 Nov 2016
REC opinion
Favourable Opinion