EMI-137 in laparoscopic colonic resections

• Research type

  Research Study

• Full title

  Intraoperative imaging of colon cancer using a fluorescent peptide (EMI-137) against the c-Met receptor

• IRAS ID

  212190

• Contact name

  David Jayne

• Contact email

  d.g.jayne@leeds.ac.uk

• Sponsor organisation

  University of Leeds

• Eudract number

  2016-003128-22

• Duration of Study in the UK

  0 years, 7 months, 1 days

• Research summary

  The aim of this study is to investigate the ability of a fluorescent medical product called EMI-137 to produce visible fluorescence in colon cancer during laparoscopic (keyhole) surgery. EMI-137 is a unique compound consisting of a cyanine dye coupled to a c-Met targeted peptide. Colon cancer along with several other types of cancer over-express the c-Met receptor. Therefore, the EMI-137 agent will accumulate in the tumour when injected in to the bloodstream 2.5 hours (range 1 to 3 hours) before laparoscopic surgery and make it fluoresce "light-up". We hypothesize the intravenous administration of EMI-137 will allow real-time intra-operative visualisation of colon cancer and any metastatic lymph nodes, aiding the safe and accurate resection of the tumour.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  17/YH/0263

• Date of REC Opinion

  19 Oct 2017

• REC opinion

  Further Information Favourable Opinion