Elucidating infection- and inflammation-associated preterm birth.
Research type
Research Study
Full title
Elucidating the mechanisms and markers of infection- and inflammation-associated preterm birth - Sheffield studies (NIHR PRIME).
IRAS ID
256135
Contact name
DOC Anumba
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
3 years, 11 months, 31 days
Research summary
Infections that may contribute to the higher rates of PTB in LMICs have rarely been investigated. Understanding which of these infections cause PTB can enable them to be prevented and treated promptly during pregnancy. We therefore plan to study features of infection in the placentas of women who experience PTB to clarify which infections contribute to high rates of PTB in LMICs and how we can prevent, detect or treat them during pregnancy. We will also investigate the presence of metabolites in the cervicovaginal fluid of pregnant women studied serially until delivered, to confirm which of them may help predict preterm birth.
REC name
London - Fulham Research Ethics Committee
REC reference
18/LO/2044
Date of REC Opinion
21 Nov 2018
REC opinion
Favourable Opinion