eLIXIR, Early Lifecourse data Cross-LInkage in Research
Research type
Research Database
IRAS ID
229566
Contact name
Robert Stewart
Contact email
Research summary
The eLIXIR project/ eLIXIR: Early Lifecourse data Cross-Linkage in Research: a Multidisciplinary partnership - linked data for research into maternal and child health
REC name
South Central - Oxford C Research Ethics Committee
REC reference
18/SC/0086
Date of REC Opinion
22 Mar 2018
REC opinion
Further Information Favourable Opinion
Data collection arrangements
We are seeking approval to establish a data resource to research the life course of mental and physical health using infrastructure developed by the Maudsley NIHR Biomedical Research Centre (BRC). This encompasses linkage and use of health records data from three NHS Trusts: South London and Maudsley NHS Foundation Trust (SLaM), Guys and St Thomas NHS Foundation Trust (GSTT) and King’s College Hospital NHS Foundation Trust (KCH).
A core platform will be developed linking records from pregnant women, infants and children. The population base is pregnant women and children receiving care from KCH and GSTT and people receiving mental health care from SLAM. This covers a catchment of around 600,000 residents predominantly residing in Lambeth and Southwark. The primary source of maternity data will be ‘BadgerNet’ maternity collected by GSTT and KCH, which contains structured information from antenatal and obstetric care and details on the new born before discharge from maternity care. Local neonatal data will initially focus on BadgerNet neonatal which records clinical care in neonatal intensive care and special care baby units. Mental healthcare data will be provided from the SLAM BRC Clinical Record Interactive Search (CRIS) resource, set up in 2008 to provide de-identified information from SLAM’s electronic health records.
Research programme
The eLIXIR project aims to support observational research in the following areas: 1. Women’s health: by enabling investigation of a) relationships between pre-pregnancy physical and mental health, common disorders of pregnancy and pregnancy outcomes, b) the long term consequences of maternal physical and mental health disorders during pregnancy for the mother’s health, c) the hypothetical efficacy of interventions at the population level arising from randomised controlled trials, e.g. lifestyle, pharmacological, devices, diagnostics to improve maternal physical and/or mental health in the short and longer term. 2. Infant/child health: by enabling investigation of a) relationships between maternal physical and mental health disorders in pregnancy, and longer term consequences for the physical and mental health of the child, b) relationships between adverse events and exposures in the foetal and neonatal period and the long term consequences for physical and mental health of the child, c) the efficacy of interventions at the population level to reduce the adverse impact of early life events and exposures on the child. 3. Mental Health: by enabling investigation of a) interrelationships between physical and mental health disorders during pregnancy and pregnancy outcomes b) relationships between maternal and childhood mental health, and c) associations between mental and physical health in women, and in children. 4. Implementation Science and Public Health: by enabling evaluation of new pathways of care/guideline recommendations to improve maternal and or child physical and/or mental health, and determination of associated health care costs.
Research database title
The eLIXIR project/ eLIXIR: Early Lifecourse data Cross-Linkage in Research: a Multidisciplinary partnership - linked data for research into maternal and child health
Establishment organisation
The South London and Maudsley NHS Foundation Trust
Establishment organisation address
Biomedical Research Centre (BRC) Nucleus, Mapother House
The Mausley Hospital,
Denmark Hill, London
SE5 8AF