EIB mediator study
Research type
Research Study
Full title
Mediator release during exercise-induced bronchoconstriction (EIB)
IRAS ID
240210
Contact name
Pascale Kippelen
Contact email
Sponsor organisation
Brunel University London
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
8666-NHS-Apr/2018- 1243, Brunel University UREC acceptance reference
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
Exercise induced-bronchoconstriction (EIB) is a transient narrowing of the airways that occurs during or shortly after strenuous exercise. The prevalence of EIB in asthmatic patients is estimated around 30-50%, but EIB can also occur in individuals without asthma (especially children, army recruit forces, and elite athletes). Controversy remains about the mechanisms - and especially the molecules - that cause the airways to narrow after exercise. Technological advancement have opened new avenues in the measurement of inflammatory molecules in biological fluids (including urine and blood). The measurements of these molecules may help to explain why EIB occurs, and how we can best treat EIB. \n\nOur aim is to utilise a novel technique (called mass spectrometry) to analyse the molecules (or mediators) released by the body when EIB occurs. \n\nParticipants will attend a screening visit during which they will complete an exercise challenge (to determine the presence of EIB). A skin prick test will also be conducted to establish if participants are sensitised to common allergens. Following the screening visit, patients with EIB will be asked to perform two further exercise challenges on separate days: one while inhaling temperate dry air, and one while inhaling hot humid air (the latter is known to block EIB). Lung function and breathing discomfort will be recorded, and urine and blood samples will be collected, before and at various time points after exercise. As a control condition, participants will also attend one visit during which no exercise will be performed. \n\nParticipants aged 18-50yr, with diagnosed asthma and/or EIB, will be included in the study. 12 participants will complete 4 visits (lasting between 90 min and 4.5h). The study will take place on Brunel University London campus, Uxbridge. Urine and blood samples will be sent to the Karolinska Institutet, Stockholm, Sweden for analysis.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
18/LO/1066
Date of REC Opinion
9 Aug 2018
REC opinion
Further Information Favourable Opinion