Efficiency of Presurgical Basal Cell Carcinoma margin mapping V02
Research type
Research Study
Full title
Efficiency of Presurgical Basal Cell Carcinoma margin mapping using Optical Coherence Tomography
IRAS ID
240419
Contact name
Martin Johns
Contact email
Sponsor organisation
Michelson Diagnostics Ltd
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Basal Cell Carcinoma (BCC) is the most common malignancy in humans. Its incidence is continuously increasing. The head and neck areas are most commonly affected due to their increased lifetime exposure to sun compared to other body parts. BCC is often treated by surgical excision which has high cure rate compared to other treatment modalities, but leaves a visible scar which can affect the quality of life of the patient, depending on the location and size of the excision. Mohs Micrographic Surgery (MMS) was developed to minimize the size of the surgical excision whilst maintaining very high cure rate. The main drawback of MMS is that repeated surgery procedures are usually required to eliminate all of the tumour using specialist resources located at the clinic.
Optical Coherence Tomography (OCT) allows non-invasive in-vivo imaging of superficial skin lesions. It is in routine clinical use for diagnosis of BCCs, and the diagnostic sensitivity and specificity is well established in published multi-centre trials. A further potential application of OCT is the pre-surgical mapping of the lateral margins of BCC. If the margins of a BCC were accurately known prior to commencing an MMS treatment, the treatment could be performed much more quickly, resulting in shorter patient stays and more efficient use of surgical and operating room resources. Previously published research has already shown that OCT mapping of BCC margins is more accurate than clinical assessment; the objective of the present study is to demonstrate that pre-surgical mapping of BCC margins with OCT is also more efficient.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/0248
Date of REC Opinion
22 Mar 2018
REC opinion
Favourable Opinion