Effects of zinc-containing toothpaste on oral malodour
Research type
Research Study
Full title
A 12h effect of zinc-containing toothpaste on oral malodour, on types and numbers of microbes
IRAS ID
227232
Contact name
Saliha Saad
Contact email
Sponsor organisation
University of the Westof england
Duration of Study in the UK
0 years, 6 months, 27 days
Research summary
1 Oral malodour may arise from organisms on the surface of the tongue. In particular, it is thought that certain Gram-negative anaerobes are responsible for this condition. They possess enzymes that allow biotransformations of substrates (e.g. cysteine, me-thionine, glutathione, lysine, arginine and tryptophan) into volatile organic compounds (VOC) including volatile sulphur compounds (VSC). By measuring breath parameters (volatile odor compounds or VOC’s by SIFT-MS) and sampling of tongue biofilm for numbers and types of microbial species, and metabolomics, and genomics at baseline, changes in breath odour parameters, quantity or type of microorganisms may be detected. Of particular interest is to detect the extent of any ecological shifts that may occur. The results of this study could substantially influence the development of formulations that could be used to reduce malodour and subsequently relieve the stress and discomfort that this condition causes in many humans.
REC name
Wales REC 1
REC reference
17/WA/0170
Date of REC Opinion
22 Jun 2017
REC opinion
Further Information Favourable Opinion