Effects of the D3 Antagonist GSK598809 on Food Reward & Reinforcement

• Research type

  Research Study

• Full title

  A single-blind, randomized, placebo controlled, two-period crossover fMRI study to investigate the effects of the D3 antagonist GSK598809 on neural and behavioural responses to food reward and reinforcement after a single oral dose of GSK598809 in overweight and obese subjects

• IRAS ID

  8363

• Contact name

• Sponsor organisation

  GlaxoSmithKline

• Eudract number

  2008-004918-26

• ISRCTN Number

  N/A

• Research summary

  This study will examine ifGSK598809 (which blocks the effects of dopamine) can reduce people's cravingfor food. This will be performed using a scan called functional MRI andpsychological tasks. If GSK598809 can reduce the craving for certain foods, itmay indicate to us that this drug may be a possible new treatment forcontrolling overeating and ultimately obesity.

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  08/H0709/70

• Date of REC Opinion

  14 Nov 2008

• REC opinion

  Favourable Opinion