Effects of oral formulations on oral malodour version 1
Research type
Research Study
Full title
The effects of oral formulations on oral malodour parameters and tongue microbiology
IRAS ID
163143
Contact name
Saliha Saad
Contact email
Sponsor organisation
University of the West of England
Clinicaltrials.gov Identifier
HAS-BBAS-14-001,
Duration of Study in the UK
0 years, 6 months, 8 days
Research summary
Oral malodour may arise from organisms on the surface of the tongue. In particular, it is thought that certain Gram-negative anaerobes are responsible for this condition. They possess enzymes that allow biotransformations of substrates (e.g. cysteine, me-thionine, glutathione, lysine, arginine and tryptophan) into volatile organic compounds (VOC) including volatile sulphur compounds (VSC). By measuring breath parameters (volatile odor compounds or VOC’s by SIFT-MS) and sampling of tongue biofilm and saliva for numbers and types of microbial species, and metabolomics, and genomics at baseline, changes in breath odour parameters, quantity or type of microorganisms may be detected. Of particular interest is to detect the extent of any ecological shifts that may occur. The results of this study could substantially influence the development of formulations that could be used to reduce malodour and subsequently relieve the stress and discomfort that this condition causes in many humans.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
14/EM/1240
Date of REC Opinion
14 Nov 2014
REC opinion
Further Information Favourable Opinion