Effects of machine perfusion on cadaveric kidneys for transplantation.
Research type
Research Study
Full title
A study to determine the metabolic effects of machine perfusion on cadaveric kidneys for transplantation.
IRAS ID
184195
Contact name
Jay Nath
Contact email
Sponsor organisation
Birmingham Clinical Research Office (Research and Development)
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
How does machine perfusion effect deceased donor kidneys for transplantation.
Kidney transplantation is the best treatment for patients with kidney failure. Most donated kidneys in the UK come from deceased individuals who have agreed to donate their organs after death.
When kidneys are removed from deceased individuals, there is variable delay before the kidney can be transplanted into an appropriate patient. During this time the kidney is normally stored in a cool box which helps preserve the kidney before it is transplanted. During storage damage can occur to the kidney which can mean it is slow to work following transplantation or doesn't work as well long term. An alternative to static cold storage is machine perfusion which in addition to providing a cold environment provides circulation of fluid through the kidney. Several large international studies have indicated that this is beneficial and improves outcomes for these kidneys. Machine perfusion may also 'improve' less healthy kidneys and allow extra time to assess the kidney and prepare the patient for surgery.
We have recently demonstrated (study RRK4459) that the metabolism during machine perfusion is pivotal to the post transplant kidney function. This study will allow more informative metabolic information to be gained during the machine perfusion process and it is hoped that such knowledge will allow improvement of the machine perfusion process and hence the kidney transplant process in the future.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
15/EM/0328
Date of REC Opinion
7 Sep 2015
REC opinion
Further Information Favourable Opinion