Effects of Inorganic Nitrite on cardiac and skeletal muscle: CHF

  • Research type

    Research Study

  • Full title

    The Effects of Inorganic Nitrite on cardiac and skeletal muscle: Physiology, Pharmacology and Therapeutic Potential in patients with Chronic Heart Failure



  • Contact name

    Michael P Frenneaux

  • Contact email


  • Eudract number


  • Research summary

    Previous studies have shown that interventions modestly increasing blood nitrite, improves muscle function during exercise. Inorganic nitrate in the diet is absorbed into the bloodstream, concentrated in the saliva and reduced by bacteria in the mouth to nitrite, which is then absorbed into the bloodstream. Although evidence indicates that nitrite increases muscle metabolic efficiency, the mechanisms responsible for this dramatic effect remains unknown. The purpose of this 3 month study is to look at the effects of inorganic nitrate supplementation on left ventricular function and exercise capacity.

  • REC name

    Scotland A REC

  • REC reference


  • Date of REC Opinion

    8 May 2012

  • REC opinion

    Further Information Favourable Opinion