Effects of Bowel Preparation on Fluid and Electrolyte Status v1.0
Research type
Research Study
Full title
Assessing The Impact Of Bowel Preparation On Fluid Shift And Electrolytes Imbalance Prior To Colonoscopy
IRAS ID
274026
Contact name
Praminthra Chitsabesan
Contact email
Sponsor organisation
York Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
York Teaching Hospital Foundation trust (YTHFT) performs approximately 3000 colonoscopies every year and at least 10% of these patients require ‘extra bowel preparation’ and a repeat colonoscopy, with many more needing extended procedures to facilitate views. These extended procedures further increase the risks associated with the bowel preparation, especially for the elderly and those with multiple chronic diseases. Given that most complications have centered around fluid and body salt (electrolyte) shifts, there has been very little investigation of this topic.
Bioelectrical impedance analysis is a non-invasive, low cost approach for body composition measurements and assessment of clinical condition. It can provide accurate measurement of hydration status. However, there is very limited research specifically utilising bioimpedance to measure the hydration status pre- and post-bowel preparation.
When bioimpedance is combined with blood tests, we can evaluate the physiological effect of bowel preparation. We aim to be the first to accurately detect and measure hydration changes using bioimpedance pre- and post- bowel preparation. We hope to correlate these changes with electrolyte levels pre- and post-bowel preparation (before colonoscopy) via routine blood samples.
We aim to establish an expected “baseline” fluid and electrolyte shift in individuals with no known comorbidities between the ages 60-75, in order to:
1. Better understand the extent bowel preparation impacts on the fluid and electrolyte status in this age group.
2. Set up criteria for identifying patients who would benefit from inpatient bowel preparation based on the degree of recorded physiological disturbances.
This is a single centre study taking place at YTHFT. We aim to identify suitable patients from those attending the hospital’s fast track referral clinics.
Participants would attend for two study visits, both coinciding with planned appointments and involving a bioimpedance measurement and blood test. The first following referral for colonoscopy and the second following bowel preparation.
REC name
London - Bromley Research Ethics Committee
REC reference
19/LO/1943
Date of REC Opinion
23 Jan 2020
REC opinion
Favourable Opinion