Effects of Agent Formulations on Oral Malodour

• Research type

  Research Study

• Full title

  Effects of Agent Formulations on Oral Malodour Parameters and Tongue Microbes Compared with Control

• IRAS ID

  178410

• Contact name

  Saliha Saad

• Contact email

  saliha.saad@uwe.ac.uk

• Sponsor organisation

  University of the West of England

• Duration of Study in the UK

  0 years, 3 months, 30 days

• Research summary

  Oral malodour may arise from organisms on the surface of the tongue. In particular, it is thought that certain Gram-negative anaerobes are responsible for this condition. They possess enzymes that allow biotransformations of substrates (e.g. cysteine, me-thionine, glutathione, lysine, arginine and tryptophan) into volatile organic compounds (VOC) including volatile sulphur compounds (VSC). By measuring breath parameters (volatile odor compounds or VOC’s by SIFT-MS) and sampling of tongue biofilm for numbers of microbial species at baseline, changes in breath odour parameters, quantity of microorganisms may be detected. The results of this study could substantially influence the development of formulations that could be used to reduce malodour and subsequently relieve the stress and discomfort that this condition causes in many humans.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  15/NW/0316

• Date of REC Opinion

  2 Apr 2015

• REC opinion

  Favourable Opinion