Effects of a walking exercise programme on Endothelial Function v8
Research type
Research Study
Full title
EFFECTS OF WALKING EXERCISE PROGRAMME ON ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH A HEALTHY PROFILE, HIGH RISK OF DEVELOPING TYPE 2 DM OR TYPE 2 DM
IRAS ID
248559
Contact name
SULTANA RAZIA
Contact email
Sponsor organisation
Queen Margaret University
Duration of Study in the UK
1 years, 1 months, days
Research summary
Diabetes mellitus (DM) affects a high proportion of people and increases the risk of conditions resulting from blood vessel disease like heart attacks and poor circulation to the limbs. Long term DM may cause structural and compositional changes to blood vessel walls (called vascular endothelium dysfunction). There is evidence to suggest that persistent high blood glucose (sugar) levels in DM triggers the process that leads to blockages and stiffening of the blood vessel walls responsible for the microvascular (small blood vessel) and macrovascular (big blood vessel) complications in DM. Problems with how the blood vessel wall reacts and works is the pivotal early stages in blood vessel wall damage and this can be measured non-invasively by a medical devices called the Vicorder (this is similar to the blood pressure device that your doctor or nurse uses).
Exercise, like for example, regular walking, is one of the essential components of management of DM as well as prevention of its complications, but there are only a few studies that have reported on the effects of exercise on blood vessel wall problems, which can be evaluated non-invasively by measuring the Pulse Wave form. This research work will be held on three different groups, such as healthy group, high risk for diabetes and diabetes group. This study will investigate the effects of regular exercise, in this case walking, on blood vessels by using the Vicorder medical device and analysing the pulse wave form.
REC name
London - Bromley Research Ethics Committee
REC reference
18/LO/2244
Date of REC Opinion
19 Apr 2019
REC opinion
Further Information Favourable Opinion