Effect on EPCs by statin loading in 'all comers' with ACS
Research type
Research Study
Full title
The effect on Endothelial progenitor cells (EPCs) by statin loading in “all comers” with an Acute Coronary Syndrome (ACS).
IRAS ID
199402
Contact name
Robert Butler
Contact email
Sponsor organisation
University Hospitals of North Midlands NHS Trust
Eudract number
2016-000355-27
Duration of Study in the UK
0 years, 6 months, 30 days
Research summary
Cardiovascular disease is a major cause of morbidity and mortality worldwide. There are a number of risk factors for coronary artery disease and all to often patients admitted with an acute coronary syndrome have these comorbidities. The main stay of treatment of such patients is to perform coronary angiography and if required coronary angioplasty.
Previous studies have shown a link between endothelial progenitor cell (EPC) count, coronary artery disease and statin therapy or loading, however these studies have excluded patients with significant comorbidities and therefore have not truly represented “real life” patients.
This pilot study will assess EPC response in patients that are able to undergo coronary intervention as part of their normal clinical management under current guidelines regardless of pre-existing comorbidities. We believe this will allow representation of “real world” patients.REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
16/WM/0072
Date of REC Opinion
10 Mar 2016
REC opinion
Further Information Favourable Opinion