Effect of vitamin-D on Bone health of HIV patients
Research type
Research Study
Full title
Effect of low dose oral vitamin-D and calcium supplement on bone mineral density changes in individuals with HIV infection: a retrospective cohort study.
IRAS ID
129585
Contact name
Satyajit Das
Contact email
Sponsor organisation
Coventry and Warwickshire partnership NHS trust
Research summary
There is a growing concern about bone health in HIV positive patients among clinicians & patients themselves. Several observational studies have noted very high rates of low vitamin D in those patients.
Questions remain regarding the actual health consequences of low vitamin D In people living with HIV. We are conscious that our colleagues in other units are sharing the same concerns of bone health in people living with HIV.
Research is the pillar of knowledge, and it constitutes an integral part of progress.
We are examining our clinical practise in this matter and as researchers we developed a research protocol which we will adhere to, is mainly a retrospective
We will strive for honesty in all scientific communications, results, data reporting, methods and procedures, and publication.
We will protect patient’s confidentiality and patient’s records through out our research process.
Individuals with low vitamin D level may be at risk of having thin bones, this sometimes increase the risk of bone fracture particularly when it is associated with other factors such as older age, white ethnicity, and low body weight, smoking, and alcohol abuse, history of rheumatoid arthritis, steroid use and osteoporosis.
The Department of Health recommends 10 micrograms of oral vitamin D (400 IU) to be given to certain categories of people including people aged 65 years and over and people not exposed too much sunlight.
People included in this study are patients with low vitamin D levels who are taking oral vitamin D and calcium tablets as part of their treatment package. We would like to take a look back at vitamin D levels along with other test results to ensure that bone health has improved along with routine lifestyle in patients attending HIV clinic in Coventry. The study will take 6 months.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
14/WM/0070
Date of REC Opinion
3 Apr 2014
REC opinion
Favourable Opinion