Effect of Vitamin D and Vibration on Bone – VibeD Study
Research type
Research Study
Full title
Effect of Vitamin D and Whole Body Vibration on High Resolution peripheral Quantitative Computed Tomography (HR-pQCT) Parameters of the Distal Tibia
IRAS ID
225440
Contact name
Amaka C Offiah
Contact email
Sponsor organisation
Sheffield Children's Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Osteoporosis is a global health issue associated with negative health and economic consequences. Osteoporosis increases bones' susceptibility to fracture from normal daily activities that should not ordinarily cause fractures. Peak bone mass (PBM) is the amount of bone tissue that is acquired when the skeleton becomes mature. Reaching maximum PBM is important as it can help to protect the skeleton form osteoporosis and reduce future fracture risk.
Whole body vibration (WBV) is a relatively new training approach that aims to enhance bone health. This requires that a person stands on a platform that vibrates and passes its energy to the muscles and bones, which can lead to improvement in bone health. However, to achieve the maximum benefits of this process, sufficient amounts of vitamin D are required. This is supported by work on animal models undertaken at the University of Sheffield which showed that mechanical loading is most effective when combined with a diet fortified with high amounts of vitamin D, suggesting that a combination of vitamin D supplementation and an adequate amount of mechanical loading is beneficial to bone. The current study will examine the truth of this hypothesis when applied to humans. Participants in this study will undergo high resolution peripheral quantitative computed tomography (HR-pQCT) scan of their non-dominant distal tibia (leg bone), as well as vitamin D measurements at two time points; before the beginning of the intervention and at the end of the intervention after three months at the end of their involvement in the study. HR-pQCT provides microscopic detail about the structure and allows assessment of the strength of bone. The current study will deepen our knowledge regarding bone response to mechanical stimuli and high dose of vitamin D.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
17/YH/0254
Date of REC Opinion
23 Aug 2017
REC opinion
Further Information Favourable Opinion