Effect of oral isotretinoin on acne associated miRNAs (ISOMIR)
Research type
Research Study
Full title
A pilot observational study on the effect of oral Isotretinoin (ISO) on circulating acne-associated miRNAs (ISOMIR)
IRAS ID
359252
Contact name
Alison Layton
Contact email
Sponsor organisation
University of York
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Acne is a widespread inflammatory skin disorder affecting millions worldwide, with a complex pathophysiology involving inflammation, sebum overproduction, and bacterial colonization. Oral isotretinoin is the most effective treatment for severe or treatment-resistant acne and uniquely targets all major contributing factors, including reducing sebum production, inflammation, and Cutibacterium acnes levels. Though its exact molecular mechanism is unclear, studies suggest it induces sebaceous gland apoptosis via NGAL, alters gene expression, impacts immune response, and affects hormone signaling.
Acne scarring, affecting up to 90% of cases, is linked to severity and duration of acne, and may be triggered even by mild inflammation in genetically predisposed individuals. Scarring results from prolonged immune responses and dysregulation in cytokines and growth factors. Research shows that individuals who scar exhibit a prolonged immune response with an adaptive component, compared to those who do not scar.
Recent interest focuses on identifying biomarkers to predict scarring. MicroRNAs (miRNAs), especially miR-21, miR-150, and miR-223, are overexpressed in acne lesions and uninvolved skin of patients who scar, and also circulate at higher levels in such individuals. Isotretinoin has been shown to reduce these miRNAs. Notably, miR-223, largely expressed in neutrophils, plays a role in inflammation and skin scarring.
The current study aims to evaluate how isotretinoin influences plasma levels of acne-associated miRNAs and inflammatory cytokines (IL-6, IL-8, IL-17), and their correlation with clinical outcomes and scarring. It seeks to improve understanding of molecular mechanisms behind acne and scarring, potentially leading to predictive tools and targeted therapies.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
25/SW/0134
Date of REC Opinion
30 Oct 2025
REC opinion
Favourable Opinion