Effect of macronutrient composition on post-bariatric hypoglycaemia
Research type
Research Study
Full title
The effect of macronutrient composition on post-bariatric hypoglycaemia
IRAS ID
286017
Contact name
Tricia Tan
Contact email
Sponsor organisation
IMPERIAL COLLEGE LONDON
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
One of the best treatments for obesity and diabetes is weight loss surgery and in particular gastric bypass surgery. Although this surgery is successful in helping people lose weight and to control high blood sugar levels, one of the side effects is that people can experience low blood sugar levels, particularly after eating. This is known as post-bariatric hypoglycaemia (PBH). PBH can be very debilitating when it occurs and the treatment for this is not clear. We know that modifying diet can be useful to control the swings of blood sugar that occur in this condition, but it is not completely known which the best diet is.
In this project, we plan to study people with PBH. We plan to test out different types of meals such as carbohydrate-containing meal, a 'mixed' meal that contains fat, carbohydrates and protein, and a high protein meal. We will measure their sugar levels through the day using a sensor that is attached to the skin, and look for any differences in which the body reacts to the different types of meal in terms of blood sugar and hormone levels. In addition, we plan to check if the body reacts to the low blood sugar levels by producing substances that promote inflammation as there have been previous studies that link the occurrence of PBH with the occurrence of inflammation.
REC name
Wales REC 7
REC reference
21/WA/0064
Date of REC Opinion
31 Mar 2021
REC opinion
Further Information Favourable Opinion