Effect of lycopene on sperm quality in men attending fertility clinic
Research type
Research Study
Full title
A randomised placebo-controlled trial to investigate the effect of lactolycopene on sperm quality in men with a low total motile sperm count: a pilot study.
IRAS ID
311219
Contact name
Jonathan Skull
Contact email
Sponsor organisation
Sheffield Teaching Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 9 months, 30 days
Research summary
This study aims to investigate the effect of 14 mg daily lactolycopene for 12 weeks on semen quality in men with low motile sperm concentration (less than 20 million motile sperm per ejaculate). Typical semen quality markers (motility, concentration, morphology) will be measured prior to and following supplementation with either lactolycopene or placebo. Other markers of sperm function such as markers of oxidative stress and levels of DNA fragmentation will be compared between the two groups. The study aims to address whether improvements in semen quality previously seen in healthy males (Williams et al. 2020) will also be seen in men with poor testicular function and poor sperm quality. \n\nHypothesis: Supplementation with lactolycopene will improve testicular function and semen quality in men with a low motile sperm concentration.
REC name
South West - Central Bristol Research Ethics Committee
REC reference
22/SW/0167
Date of REC Opinion
9 Dec 2022
REC opinion
Further Information Favourable Opinion