Effect of L. casei Shirota in patients newly treated with PPI.

• Research type

  Research Study

• Full title

  Investigation of the effect of L. casei Shirota on preventing abdominal symptoms and small intestinal bacterial overgrowth in patients with gastro-oesophageal reflux disease newly treated with proton pump inhibitors: A randomised controlled pilot trial.

• IRAS ID

  254275

• Contact name

  Etsuro Yazaki

• Contact email

  e.yazaki@qmul.ac.uk

• Sponsor organisation

  Queen Mary University of London

• Duration of Study in the UK

  1 years, months, days

• Research summary

  To study the efficacy of Yakult in preventing small intestinal bacterial overgrowth development during the first eight week proton pump inhibitor treatment (PPI) in patients with gastro-oesophageal reflux disease. We will collect stool samples three times during the study to examine alteration of microbiota by PPI and Yakult. The stool samples will be tranferred to Yakult Lab (Belgium) to carry out processing and microbial analysis.

• REC name

  West Midlands - South Birmingham Research Ethics Committee

• REC reference

  19/WM/0250

• Date of REC Opinion

  18 Nov 2019

• REC opinion

  Further Information Favourable Opinion