Effect of Intermittent Pressure in Patients with PAD
Research type
Research Study
Full title
PAD Protocol. Mechanistic Insights into changes in peripheral blood flow following intermittent negative pressure.
IRAS ID
250828
Contact name
Faisel Khan
Contact email
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 8 months, 0 days
Research summary
Atherosclerosis occurs when blood supply to the lower limbs is restricted upon accumulation of fat in the arteries. The initial symptom is pain in lower limbs followed by hypoxia and ulceration. The literature has indicated that intermittent negative pressure (INP) can be used to reduce the pain and facilitate wound healing. INP is a non-invasive technique that aims to increase blood flow in lower limbs and foot but there is no evidence to prove these findings. In this PhD studentship, we aim to investigate the underlying mechanisms that are involved in changes in blood flow following application of INP. The Flow-Ox ‘boot’ will be used to apply INP for periods ranging from 4-8 weeks for an hour twice per day to the lower limbs to determine the effects of INP on vascular function and blood flow. Specifically, vascular tests such as assessments of endothelial function (laser perfusion imaging with iontophoresis, flow mediated dilatation of the brachial artery), arterial stiffness (pulse wave analysis), ankle-brachial pressure index (ABPI) and blood borne metabolic and inflammatory markers will be performed before and after INP application. A pain chart will be employed before and after INP application to determine whether there is any change in perception of pain felt by individuals who suffer from pain associated with lower limb vascular disease.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
19/ES/0005
Date of REC Opinion
31 Jan 2019
REC opinion
Further Information Favourable Opinion