Effect of inhaled ATP and hypotonic saline on plasma ATP levels
Research type
Research Study
Full title
Effect of inhaled ATP and hypo-osmolar solutions on blood ATP metabolites and cough in refractory chronic cough and healthy volunteers.
IRAS ID
294664
Contact name
J Smith
Contact email
Sponsor organisation
University of Manchester
ISRCTN Number
ISRCTN11791599
Duration of Study in the UK
1 years, 5 months, 28 days
Research summary
Chronic cough is a common and disabling condition. There are currently no licensed treatments and the reasons it occurs are not well understood. New drug treatments show promise but not all patients respond. Adenosine triphosphate (ATP) is believed to play a key role in chronic cough but exactly how remains unclear. This study aims to challenge chronic cough patients and health volunteers with inhaled ATP and hypotonic (low salt and chloride content) saline to see if they bring on cough and/ or cause ATP release in the blood or breath. This would help identify if there are markers that can be used to predict response to new medications in cough. This will be conducted at NIHR Manchester Clinical Research Facility. Participants will attend for 3 visits and be telephoned on a further occasion. They will undergo 3 cough challenges and blood sampling over a total period of 4 weeks per patient. We aim to recruit 20 patients per group and it is estimated to take 12 months to complete the study.
REC name
North of Scotland Research Ethics Committee 2
REC reference
21/NS/0119
Date of REC Opinion
31 Aug 2021
REC opinion
Favourable Opinion