Effect of High Flow Nasal Oxygen on Exercise Tolerance in ILD patients
Research type
Research Study
Full title
Effect of HFNO on Exercise Tolerance in Patients with Interstitial Lung Diseases during a Constant Work Rate Cycle Test Compared with the Effect Obtained using Oxygen through Nasal Cannula.
IRAS ID
299088
Contact name
Roberto A Rabinovich
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Interstitial lung disease (ILD) is a diverse group of illnesses that cause damage to the lungs through varying degrees of inflammation. One of the main problems of this disease is the drop in the levels of oxygen in the blood on the exercise, which leads to functional limitation and alteration of the quality of life of these patients. Oxygen supplementation during exercise might allow physical training at a higher level and result in more effective Pulmonary Rehabilitation (PR). Typical nasal oxygen delivered by nasal cannulas from 2 to 6 litres per minute is often insufficient to correct this drop of oxygen. Currently, some devices can deliver higher oxygen flows, these devices are called High-Flow Nasal Oxygen (HFNO), which may provide very high flows (up to 60 L/min) and utilizes an air oxygen blend allowing concentrations of oxygen from 21 to 100%. We believe that HFNO might improve the exercise capacity in patients who suffer from ILD during an exercise test called Cardiopulmonary Exercise Test (CPET), the purpose of this test is to evaluate the maximal capacity of the lungs and heart during the exercise. For this reason, the main objective of the study is to evaluate the effect of HFNO on exercise capacity measured with an exercise test on a bicycle at 75% of the maximal work load obtained from a maximal exercise test conducted the day before on a bicycle too, and compare it with the effect obtained using oxygen through a nasal cannula. This is a study of 20 patients with ILD, which will last 2 days. On the first day, weight, height, maximal exercise test on a bicycle will be taken. On the Second day patients will perform two exercise tests on a bicycle, but this time the workload will be constant, (75% of the maximal work load obtained from the maximal exercise test conducted the day before) separated by 60 minutes. Patients will receive randomly oxygen delivered via nasal cannula or HFNO. As mentioned before, the main difference between these 2 systems is that nasal cannula can deliver low flows of oxygen, whereas HFNO can deliver very high flows of oxygen.
REC name
South East Scotland REC 02
REC reference
21/SS/0046
Date of REC Opinion
29 Nov 2021
REC opinion
Further Information Favourable Opinion