Effect of dietary nitrate ingestion in stable angina.
Research type
Research Study
Full title
Investigation of the effect of dietary nitrate ingestion in stable angina.
IRAS ID
124034
Contact name
Amrita Ahluwalia
Contact email
Sponsor organisation
Queen Mary University of London
Research summary
The opening up of blocked coronary arteries using a balloon that is passed through the artery and inflated (called angioplasty) has been a revolutionary technique for improving survival in people with heart disease. However, over time, in 5-10% of patients the treated artery becomes blocked, a phenomenon called restenosis. Recent evidence suggests that dietary nitrate, a chemical found naturally in high levels in green leafy vegetables including beetroot, has a range of biological effects in the body that might reduce restenosis. In this study we will investigate the effects of increasing dietary nitrate intake in patients having balloon angioplasty. The primary aim of this research is to determine whether increasing one's dietary nitrate intake, by consuming a daily load of vegetable that has a high nitrate content, might improve long term outcome in patients who have undergone balloon angioplasty. We have shown previously that nitrate exerts effects on arteries that might prevent a heart attack. This study will test whether dietary nitrate might be useful in preventing arteries from becoming blocked in patients who are at risk of this happening.
REC name
London - London Bridge Research Ethics Committee
REC reference
14/LO/1708
Date of REC Opinion
6 Nov 2014
REC opinion
Further Information Favourable Opinion