Effect of bisphosphonates on bone
Research type
Research Study
Full title
The effect of bisohosphonate administration on bone
IRAS ID
239216
Contact name
David Gibbs
Contact email
Sponsor organisation
University of Southampton
Clinicaltrials.gov Identifier
32161, 32161
Duration of Study in the UK
6 years, 0 months, 1 days
Research summary
Bisphosphonates are medicines which are widely used in clinical practice, namely in treatment the of osteoporosis, Padgets disease of the bone, and to prevent the spread of cancer to the bone. Bisphosphonates are known to have an effect on osteoclasts, which are cells which break down bone. The effect of bishosphonate administration on other cells found in the bone, such as osteoblasts which make bone material, and osteocytes which co ordinate bone formation and bone breakdown is incompletely understood. Furthermore, the optimal duration of therapy with bisphosphonates is not known. We currently have ethical approval for the use of surplus tissue from patients undergoing surgery for hip fractures and arthritis at Southampton General Hospital (IRAS 234701). We would like to correlate the behaviour of the cells in the samples we currently receive from patients undergoing hip replacement surgery with additional patient information, namely if the patient is on bisphosphonates and other details routinely recorded in the patients notes and drug chart on admission to hospital relevant to osteoporosis.
REC name
London - Stanmore Research Ethics Committee
REC reference
18/LO/0902
Date of REC Opinion
6 Jun 2018
REC opinion
Further Information Favourable Opinion