Effect of ankle replacement during activities of daily living (TARADL)
Research type
Research Study
Full title
Biomechanical Performance of Ankle Fusion and Total Ankle Replacements During Activities of Daily Living.
IRAS ID
244600
Contact name
Anthony Redmond
Contact email
Sponsor organisation
University of Leeds
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 1 months, 30 days
Research summary
Ankle osteoarthritis is a relatively common condition involving wear and tear of the ankle joint. Patients who need treatment for ankle osteoarthritis usually have ankle fusion (AF) or total ankle replacement (TAR) surgery. AF involves screwing the bones of the ankle together.TAR replaces the damaged joint with a motion conserving mechanical joint. All previous post-operative gait studies measured patients walking on a flat surface. There is a need to understand the functional consequences on more demanding activities of daily living (ADL). These movements replicate the real-world functional demands of patients. The study will compare the biomechanics of TAR patient’s ability to return to normal range of motion compared to AF patients and control participants one year post-surgery.
There are limited studies investigating the pre-clinical wear performance of TARs, with previous studies utilising walking cycle profiles from healthy patients. These profiles do not represent the gait of TAR patient population. Therefore, the proposed study will explore the gait profiles of TAR patients during ADLs, and use them as inputs to run a clinically-relevant mechanical simulator that will determine the wear behaviour and longevity of TAR’s.
Up to 60 patients (30 AF and 30 TAR) will be identified by the relevant orthopaedic surgeon within Chapel Allerton Hospital. Up to 30 healthy control participants will also be recruited to participate in the study. Participants will attend a single appointment at the gait laboratory and asked to complete the study questionnaire (Manchester Oxford Foot Questionnaire), used to assess outcomes following foot/ankle corrective surgery. Participants will also be asked to perform a number of activities that make up part of their daily routine (e.g. flat surface walking, stair ascent/descent and slope walking) at a self-selected speed. Gait outcomes that will be recorded include: hip, knee and ankle motion, ground reaction forces, joint moments and power.REC name
East of Scotland Research Ethics Service REC 2
REC reference
19/ES/0070
Date of REC Opinion
29 Jul 2019
REC opinion
Further Information Favourable Opinion