Effect of a CRP on Molecular Mechanisms. Version 3.
Research type
Research Study
Full title
Effect of a Cardiac Rehabilitation Programme (CRP) on Inflammation and Endothelial Function in Coronary Artery Disease Patients.
IRAS ID
242655
Contact name
Ciara Hughes
Contact email
Sponsor organisation
Ulster University Sponsor
Duration of Study in the UK
1 years, 3 months, 1 days
Research summary
Background:
Research has documented that a cardiac rehabilitation programme (CRP) is capable of improving the health of coronary artery disease (CAD) patients. Yet, despite the proven benefit, CRPs are underutilised worldwide. Exercise is an important component of a CRP, and may prevent CAD patients from suffering a recurrent heart attack by improving arterial function. However, the protein molecules that may facilitate this improvement are not well understood. This study will seek to evaluate the effects of a CRP on protein molecules that may improve artery function, and investigate how CAD patients decided whether or not to participate in a CRP.
Methodology:
This proposed research project will be a pilot prospective observational cohort study. 70 post heart attack CAD patients who have been invited to take part in a CRP will be recruited between 03/09/18 - 03/12/19 from the Belfast Health and Social Care Trust (BHSCT) and Ulster Hospital. The study measurements will be taken at three “Time Points” over a 22-week period at BHSCT sites, Ulster Hospital, or an Ulster University (UU) campus. The study measurements will consist of: arterial function, a blood sample (44 millilitres), capillary blood glucose and lipid levels, and standard clinical measurements.
Dyadic interviews consisting of patients who either declined or agreed to attend a CRP and their significant other (SO) will be conducted during the pilot study to investigate how the patient decided whether or not to participate in a CRP. Each interview will be one-to-one; the patient and SO will be interviewed separately. Each patient and SO will be offered the opportunity to determine a convenient time and location for the interview to be held.
Outcome:
This study will determine the feasibility of evaluating novel molecular mechanisms, and provide detailed qualitative information that may help to provoke an increase in CRP participation.
REC name
HSC REC A
REC reference
18/NI/0166
Date of REC Opinion
3 Oct 2018
REC opinion
Unfavourable Opinion