Effect of a Central Arterio-venous Anastomosis on venous return
Research type
Research Study
Full title
The Effect of a Central Arterio-venous Anastomosis on venous return assessed by Hepatic Venous Doppler Imaging, 3D echocardiography and Thoracic Impedance
IRAS ID
263274
Contact name
Neil Sulke
Contact email
Sponsor organisation
East Sussex Healthcare NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Vasodepressor syncope or simple faints is a common condition, which can result in a significantly reduced quality of life. It is thought that the main mechanism to cause simple faints is a reduction in central blood volume resulting in reduced blood output from the heart in response to standing or a trigger e.g. blood taking. This results in a reduced blood pressure, which causes people to faint.
It has been shown in some patients that creating a passageway between the artery and vein in the groin may reduce the frequency and severity of faints in some patients but the exact mechanism is not known.
This research project will study the effect of blood flow and volume returning to the heart in 3 ways; ultrasound of the veins in the liver, ultrasound of the heart and changes in fluid volume in the chest in patients who already have a stent inserted to create a passageway in the groin compared to normal healthy participants.
We will assess changes in blood flow in 3 situations
1. When patients legs are raised to 45 degrees whilst lying flat known as a passive leg raise
2. When we apply blood pressure cuffs to patients thighs for two minutes whilst lying flat
3. When participants stand up from a lying positionAll of the tests are non invasive and will help our understanding of how passageways in the groin affect blood volume and flow around the body and how this can prevent simple faints.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
19/LO/0964
Date of REC Opinion
27 Sep 2019
REC opinion
Further Information Favourable Opinion