Edere version 1
Research type
Research Study
Full title
Methods to measure, and models to predict, the physiological changes following food intake of varying macronutrient content (Edere)
IRAS ID
216936
Contact name
John Hattersley
Contact email
Sponsor organisation
UHCW NHS Trust RD&I
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The precise relationship between glucose metabolism and energy expenditure in humans is not fully understood; the purpose of this study is to explore and develop new ways to non-invasively measure and monitor the metabolic response to variations in dietary intake.
The three areas of study will require volunteers to attend a specialised facility dedicated to advanced metabolic measurement (HMRU)They will be asked to consume prepared meals of varying macronutrient content (protein, carbohydrate and fat) as part of a balanced diet. During this time the volunteers will be measured by instrumentation which will investigate the chemical concentration in respired gases (e.g. whole-body calorimeters, metabolic carts). Standard clinical samples will be taken to be analysed at UHCW (e.g. urine, blood, saliva).
The data derived from this study will allow new tools and mathematical models to be developed that can be used to predict and simulate patient metabolic response. It is envisaged this study will give further evidence to support future research into glucose utilisation in diseased metabolic populations.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
17/NW/0277
Date of REC Opinion
2 Jun 2017
REC opinion
Further Information Favourable Opinion