ECHo CoA

• Research type

  Research Study

• Full title

  Exploring the Life Course of Hypertension in Corrected Coarctation of the Aorta: Pathophysiological Insights into the Mechanisms Leading to Persistent Hypertension.

• IRAS ID

  293605

• Contact name

  Riaz Akhtar

• Contact email

  rakhtar@liverpool.ac.uk

• Sponsor organisation

  University of Liverpool

• Duration of Study in the UK

  4 years, 0 months, 0 days

• Research summary

  Patients with a narrowing of their main artery (coarctation of the aorta) that causes a restriction of blood flow have been found to suffer from persistent high blood pressure, even after the successful repair of this narrowing through surgical intervention. The mechanisms involved in the development of coarctation of the aorta and its associated persistent high blood pressure are currently poorly understood.
  The purpose of this study is to help us better understand the development of coarctation of the aorta and gain a greater insight into the causes of long-term high blood pressure after successful surgical repair. The aim of this is to help try and learn what causes this high blood pressure, in the hope that we may be able to find a more effective treatment in the future. The information obtained in this study will also be used to guide future research in this condition.
  We will look to complete this research through the analysis of blood and tissue samples from patients with coarctation of the aorta that will be undergoing surgical repair. We aim to analyse the biomechanical and biochemical properties of the tissue samples, checking for factors such as elasticity, the concentration of elastin fibres, and stiffness in order to determine if the symptoms observed in these patients are caused by changes within the wall of the artery. Whereas in the blood samples, we will be looking for molecular biomarkers that may be involved in changing the structure of the artery wall in order to cause this disease.
  

• REC name

  London - City & East Research Ethics Committee

• REC reference

  21/PR/0208

• Date of REC Opinion

  29 Mar 2021

• REC opinion

  Further Information Favourable Opinion