EASY MRI
Research type
Research Study
Full title
EASY MRI: Evaluating Airway Sarcoidosis Pathology with MRI
IRAS ID
294795
Contact name
Nicholas D Weatherley
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHA
Duration of Study in the UK
1 years, 3 months, 1 days
Research summary
Sarcoidosis is a condition where inflamed cells clump together to form granulomas, which can lead to inflammation or scarring. It can affect any organ of the body, but most commonly affects the lungs. Symptoms can be highly variable, and some patients have no symptoms where as others may develop fatigue or breathlessness. The causes of sarcoidosis are poorly understood. It commonly affects adults in their 30’s or 40’s.
Some patients present with symptoms suggestive of involvement in the airways, such as cough. Inhalers containing steroid are commonly used, but there is a poor understanding of which patients may benefit. Part of the problem is the lack of a sensitive way of measuring these effects and knowledge of how sarcoidosis affects the airways physiologically.
We would like to know more about the disease process of sarcoidosis, particularly where it involves the airways. We will use a number of techniques in order to better understand to disease process.
In order to assess whether sarcoidosis produces changes in airway ventilation (and whether these changes are stable or change over a short time period), we will use magnetic resonance imaging (MRI) with inhaled xenon gas. During this technique, xenon and nitrogen mixture is inhaled and during a subsequent breath-hold, images of the lungs are taken. This creates a detailed view of the lung airway tree, to explore how the disease affects the airways and deeper lung tissue.
This technique will be used alongside lung function tests, commonly performed in the laboratory setting and cardiopulmonary exercise testing, to see what happens in the lungs of this group of patients when they reach peak exercise capacity.
REC name
London - Bromley Research Ethics Committee
REC reference
21/LO/0308
Date of REC Opinion
26 Apr 2021
REC opinion
Favourable Opinion