Early Haemodynamic Phenotypes in Congenital Diaphragmatic Hernia
Research type
Research Study
Full title
Investigation of heamodynamic phenotypes in congenital diaphragmatic hernia and their relationship to disease severity
IRAS ID
318553
Contact name
Neil Patel
Contact email
Sponsor organisation
NHS GG&C Research and Innovation (R&I)
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Congenital diaphragmatic hernia (CDH) is a congenital condition (birth defect) where a defect or hole in the muscle between the abdomen and chest (diaphragm muscle) allows the abdominal organs to move into the the thoracic cavity during fetal development. This is accompanied by abnormal development of the heart and lungs.
CDH is a rare condition affecting 1 in 2000 babies, but has severe consequences. Affected infants with severe CDH can be critically ill after birth. Up to 30% may not survive, and those who do may have significant ongoing health problems including affecting their heart and lungs which affect their daily function.
Our research group have been investigating the function of the heart in this condition for over 10 years, and have previously shown that early changes in heart function affect disease severity, outcome and may be important targets for treatment.
This study builds on our previous work. It will investigate heart function in the first days and weeks of life in babies with congenital diaphragmatic hernia, to understand the different patterns of heart function (phenotypes) and their relationship to antenatal measures, patient characteristics and outcomes.
We can find out this information by analysing data that has already been routinely collected in the care of infants with CDH at our hospital over the past 7 years, to which we routinely have access for clinical care. This includes data from ultrasound scans performed before and after birth, together with routine data on babies' characteristics, treatments and outcome.
We will report the combined data from all of the patients so no individual baby can be identified.
We hope and expect that this data will lead to improved understanding, better treatments and outcomes in CDH
REC name
London - Dulwich Research Ethics Committee
REC reference
25/PR/0356
Date of REC Opinion
25 Apr 2025
REC opinion
Further Information Favourable Opinion