Early beta-blockade in TBI: a pre-trial qualitative study
Research type
Research Study
Full title
Early beta-blockade in severe traumatic brain injury (EBB-TBI): a pre-randomised controlled trial qualitative study.
IRAS ID
315146
Contact name
Matt Thomas
Contact email
Sponsor organisation
North Bristol NHS Trust
Duration of Study in the UK
0 years, 8 months, 30 days
Research summary
We are running a study that aims to design a safe dose of a beta-blocker called esmolol for adults in the 24 hours after severe traumatic brain injury. This is because beta-blockers might protect the brain after trauma. The study is challenging because of the way the drug is used and the need to recruit participants quickly at a very stressful and busy time.
This study complements the intervention design study. It will focus on gathering different information from those involved with the study, both healthcare professionals and patients and relatives. Qualitative analysis of semi-structured interviews will give insights that are not available from the quantitative study. The use of mixed methods allows better understanding of the way the study runs in the real world and the impact it has or could have on patients and on practice.
This will inform the design and content of the next stage application for a multi-centre mixed methods study of esmolol.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
22/EM/0199
Date of REC Opinion
31 Oct 2022
REC opinion
Further Information Favourable Opinion