DYNAMO
Research type
Research Study
Full title
The dynamic interplay between bleeding phenotype and baseline factor level in moderate and mild hemophilia A and B
IRAS ID
248081
Contact name
Anne-Fleur Zwagemaker
Contact email
Sponsor organisation
R&D Office Manchester Royal Infirmary
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Hemophilia is an inherited bleeding disorder caused by a deficiency of clotting factor VIII (hemophilia A) or factor IX (hemophilia B). People who have hemophilia A or B experience bleeds. The amount and the severity of the bleeds seem to coincide with the clotting factor VIII and IX levels. The relationship between the bleeding pattern and the clotting factor levels has been previously studied in hemophilia A and has shown variable results. There aren’t any studies known to have investigated this in hemophilia B. The DYNAMO study is an international study that is set up to gain insight in the association between clotting factor levels and the bleeding episodes in hemophilia A and B. This knowledge will also give us more insight in the onset and the expression of the different bleeding tendencies between hemophilia A and B. The DYNAMO study is being carried out by doctors and investigators at various hospitals. Patients with mild and moderate hemophilia A or B will be asked to participate. The study involves taking an extra blood sample. This blood will be used to look at the level of clotting factor levels at the moment of blood withdrawal. In addition, we will ask patients to fill in an online questionnaire about the bleeds they experienced in the past.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
18/NW/0680
Date of REC Opinion
19 Oct 2018
REC opinion
Further Information Favourable Opinion