Dynamic Contrast Enhanced-MRI in Colorectal Liver Metastasis Resection
Research type
Research Study
Full title
Can use of Dynamic contrast Enhanced MRI (DCE-MRI) of the Liver accurately predict Quantitative Segmental Function to determine post operative remnant liver function after major resection for Colorectal Liver Metastasis?
IRAS ID
146183
Contact name
David Longbotham
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Research summary
We aim to investigate whether a new MRI technique called Dynamic Contrast Enhanced MRI (DCE-MRI) can accurately predict how well each segment of the liver functions; and so work out how much liver needs to remain after an operation to remove cancer spread to the liver from the bowel - Colorectal liver metastasis (CRLM).
In healthy liver, up to 75% can be safely removed surgically. It’s important to estimate how well the liver in patients with diseases like cancer will work before surgery. Current techniques like CT scans only estimate liver volume, and therefore cannot tell how well each segment of liver is working as a numerator of total function.
DCE-MRI uses a liver specific contrast that demonstrates blood flow into liver cells, and measures the cells ability to absorb nutrients and eliminate waste products. This could accurately estimate the liver function per liver segment and hence help plan how much liver tissue needs to be left behind at surgery.
It will be compared to recognised assessments of overall liver function; scoring systems that are calculated from various blood tests and by-the-bedside assessment. The results of the scoring systems and the results of the MRI will be analysed to see if there is any correlation.This study will include patients undergoing major surgery for their colorectal metastasis, with at least 40% of their liver being removed (3 or more anatomical segments.
REC name
Wales REC 6
REC reference
14/WA/1141
Date of REC Opinion
9 Sep 2014
REC opinion
Further Information Favourable Opinion