DYNAMIC CHANGES ON AIRWAYS AFTER FORCED EXPIRATORY MANOUVRE
Research type
Research Study
Full title
DYNAMIC CHANGES ON AIRWAYS AFTER FORCED EXPIRATORY MANOUVRE ASSESSED BY IMPULSE OSCILLOMETRY AND EXHALED NITRIC OXIDE
IRAS ID
173027
Contact name
Omar Usmani
Contact email
Sponsor organisation
Imperial College
Duration of Study in the UK
0 years, 4 months, 30 days
Research summary
Patients with lung disease may have some narrowing of the small airway tubes in the lungs which may not be detected by the usual blowing tests using in the clinics (called ‘spirometry’) which mainly detects the large air tubes. However, impulse oscillometry (IOS) is a new blowing test, which allows us to assess the narrowing of the small airways as well as the large airways.
Patients with lung disease may also have inflammation of the air tubes, which may contribute to the narrowing of the airways. We would like to measure a ‘marker’ (tests that give us an idea) of inflammation in the air tubes from the quantity of a gas found in the airways that we all blow out, called nitric oxide (NO).
We would like to use spirometry, IOS and NO tests to understand how the small airways are affected in different lung diseases and compare them to healthy people.
Four days of assessments consisting of spirometry, IOS and NO will be performed at the Royal Brompton Hospital Trust. We would also like to study how the lung function changes over the course of time (during about 60 minutes in each assessment day).REC name
London - Fulham Research Ethics Committee
REC reference
15/LO/1216
Date of REC Opinion
31 Jul 2015
REC opinion
Further Information Favourable Opinion