(duplicate) Treatment effects on hypertensive physiology
Research type
Research Study
Full title
The effects of antihypertensive treatment on the physiology of hypertensives
IRAS ID
170081
Contact name
Laurence A Gray
Contact email
Sponsor organisation
Cardiff University
Duration of Study in the UK
1 years, 7 months, 30 days
Research summary
Hypertension is a significant risk factor in the development of stroke and heart attack. Unlike other risk factors such as age, ethnicity and genetics it is modifiable. Lifestyle measures such as diet, weight loss and exercise can improve blood pressure. In addition, medicines have been developed and are currently being used to lower blood pressure. Despite an increasing array of treatments blood pressure control remains imperfect in many patients. It appears in the vast majority of patients that hypertension is due to a multitude of factors. Treatment guidelines that exist for the management of hypertension are straightforward and are based on the "A/C or D" approach. That is Ace inhibitor, Calcium channel blocker or diuretic. Patients not controlled by these three therapies should be referred on for specialist opinion. At the University Hospital Llandough we have a hypertension clinic which specialises in these difficult to manage cases. Our study aims to firstly characterise these patients' physiology. Secondly, to see how these patients' physiology changes with treatment alterations. Thirdly, we will collect outcome data such as morbidity, mortality and measures of blood flow to better determine the response to treatment. It is hoped this research will allow a more complete understanding of the mechanisms of hypertension and treatment effects in a real world setting.
REC name
Wales REC 3
REC reference
15/WA/0176
Date of REC Opinion
22 Jun 2015
REC opinion
Further Information Favourable Opinion