(duplicate) Microperimetry changes in macular disorders
Research type
Research Study
Full title
An investigation of microperimetry for monitoring retinal functional in selected macular disorders.
IRAS ID
350185
Contact name
Winfried Amoaku
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 2 months, 31 days
Research summary
The retina is the light-sensitive film at the back of the eye. The macula (with the fovea at its centre) is the part of the retina responsible for fine detailed vision, colour vision, and maintaining steady gaze on points/objects (called ‘fixation’).
Macular sensitivity refers to how responsive the macula is to light, including ability to detect and focus on objects, and maintain a steady gaze on points of interest (‘fixation’). It is measured with a special device called the Macular Integrity Assessment (MAIA) microperimetry (MP) system. While standard eye tests measure vision in the fovea, measuring sensitivity across the wider macula would provide more complete picture of visual function. Macular sensitivity changes are one of the earliest signs of retinal diseases, before blurry vision occurs. Currently, MP is not used routinely in UK NHS clinical practice.
The commonest retinal diseases are age-related macular degeneration (AMD) and diabetic retinopathy (DR). There are 2 types of AMD: dry and wet.
The main goal of this research is to measure macular sensitivity in people with these common macular disorders using the MAIA using a standard, and shorten programme. These measurements will be compared to changes in the macula obtained with non-invasive imaging techniques of optical coherence tomography (OCT), acquired as part of their routine care.
Participants (after consent) will have MP done at enrolment, then 6 and 12 months later. We will access information from their eye clinic records, including OCT images/scans of the retina. No treatment interventions are planned, and participants standard of care will not be affected.
In addition, we will invite a group of normal controls (i.e. persons who do not have any diseases of the back of their eyes) for comparison. This will assure validity of our findings. Normal controls will attend only once. After consent is obtained, these healthy participants will have MP, and imaging of the macula with OCT.
This study will form part of a research/educational thesis and provide additional data to complement previous research on the topic.REC name
London - City & East Research Ethics Committee
REC reference
24/PR/1319
Date of REC Opinion
31 Oct 2024
REC opinion
Further Information Favourable Opinion