(duplicate) Investigating neurovascular coupling in multiple sclerosis patients
Research type
Research Study
Full title
Investigating neurovascular coupling in multiple sclerosis patients – A combined fMRI/MEG approach
IRAS ID
171238
Contact name
Valentina Tomassini
Contact email
Sponsor organisation
Cardiff University(Research and Innovation Services)
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system causing disability. Previous work has shown inflammation affects vascular function in the brains of these patients possibly compromising blood supply. When neural activity increases within the brain this is met by an increase in blood flow to the area in use, a process known as neurovascular coupling. Using different intensities of a visual stimulus produces a graded response of both blood flow and neural activity and we propose to use this in conjunction with neuroimaging techniques to measure altered neurovascular coupling in MS in comparison to healthy control subjects. This work would be a precursor to studies that investigate treatments to restore neurovascular function and potentially limit damage to the brain in MS.
REC name
Wales REC 3
REC reference
15/WA/0003
Date of REC Opinion
28 Jan 2015
REC opinion
Further Information Favourable Opinion