Dual Focus Narrow Band Imaging for the Diagnosis of Coeliac Disease
Research type
Research Study
Full title
A prospective observational cohort study to assess the use of Dual Focus Narrow Band Imaging for the Endoscopic Diagnosis of Coeliac Disease
IRAS ID
222807
Contact name
Bu'Hussain Hayee
Contact email
Sponsor organisation
King's College Hospital NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 31 days
Research summary
Coeliac disease can present in different ways and it is important to look for this in people experiencing weight loss, abdominal discomfort, bloating, diarrhoea and/or a low blood count (anaemia) as it can then be treated. Gastroscopy is required for patients experiencing the above symptoms or if blood tests indicate the possibility of coeliac disease for confirmation of the diagnosis. To confirm or exclude coeliac disease, it is routine practice to take samples (biopsies) from the small bowel at the time of gastroscopy. However, these biopsies sometimes do not identify coeliac disease if they do not catch an affected area. Biopsies are a standard part of most endoscopy tests.
A technique called dual focus narrow band imaging (NBI) uses specific light wavelengths highlighting blood vessel patterns making it much easier to see any abnormal areas. This technology is inbuilt in the gastroscopes and just requires a touch of a button to use. It is possible that this technology could mean that coeliac disease could be diagnosed during the gastroscopy and not require biopsy at all.
We are testing whether the use of dual focus NBI can diagnose coeliac disease without needing to take samples. This could potentially enable a diagnosis of coeliac disease to be made directly at the time of gastroscopy meaning patients would not need to wait for biopsy results which could also miss the diagnosis. Additionally we will be assessing whether this imaging technique can be used accurately by endoscopy doctors of varied experience by reviewing patient anonymised video recordings after training in dual focus NBI.REC name
East of Scotland Research Ethics Service REC 1
REC reference
17/ES/0099
Date of REC Opinion
3 Aug 2017
REC opinion
Further Information Favourable Opinion