Drug metabolism in human hepatocytes to aid drug discovery_V1
Research type
Research Study
Full title
Assessment of drug metabolism in human hepatocytes to aid drug discovery studies in oncology research
IRAS ID
280588
Contact name
Stuart Farrow
Contact email
Sponsor organisation
Cancer Research technology Ltd
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
The use of human hepatocytes will help investigate the metabolic stability of potential drugs and understand potential safety issues. Human hepatocytes will be incubated with potential drugs in order to measure the drug clearance and identify potential metabolites.
Human hepatocytes will be acquired from commercial suppliers and stored on site until their use and subsequent destruction. The samples received will be anonymous and the donors will have given their consent for the tissue to be used in research. It is preferable to acquire a large batch of cells and store these for subsequent experiments rather than acquiring cells for each experiment to avoid issues with batch to batch variation.
REC name
Wales REC 7
REC reference
20/WA/0140
Date of REC Opinion
4 May 2020
REC opinion
Favourable Opinion