Drug Level Monitoring for PrEP
Research type
Research Study
Full title
Urine drug level monitoring (DLM) to support HIV pre-exposure prophylaxis (PrEP) adherence
IRAS ID
290315
Contact name
John Saunders
Contact email
Sponsor organisation
Noclor
Clinicaltrials.gov Identifier
Z6364106/2021/03/55 clinical research, UCL Data Protection Office registration
Duration of Study in the UK
0 years, 4 months, 1 days
Research summary
HIV pre-exposure prophylaxis (PrEP) is a medicine that HIV negative people take to stop them getting HIV. We know that PrEP is very effective in preventing HIV as long as it’s taken correctly. But if people miss pills then PrEP is less likely to work.
It might be helpful for doctors and nurses to know when people have and have not taken their PrEP. There is a test which measures the level of PrEP in the urine. This tells us whether someone has taken PrEP in the last two days. The urine test has been checked in the lab and with people using PrEP. So we know that it measures PrEP levels correctly. We don’t yet know how people would feel about taking the test.
We would like to understand whether patients feel it would be ok to have this kind of test in the sexual health clinic. We also want to know if this test can be done in clinics.
People who use PrEP will be invited to take part in the study when they go to the sexual health clinic for their usual PrEP appointment. Being in the study involves completing a survey asking about PrEP use and their feelings about the urine test. After that, people in the study would be given the option to do the urine test too. There are no follow up appointments in this study.
REC name
London - Fulham Research Ethics Committee
REC reference
21/LO/0386
Date of REC Opinion
25 May 2021
REC opinion
Favourable Opinion