DRIVEN v0.6
Research type
Research Study
Full title
A multicentre retrospective analysis of pre-operative prognostic biomarkers in resected right colon cancer and the influence of type of operative approach on survival
IRAS ID
287131
Contact name
Gina Brown
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
5357, Sponsor's Reference Number (CCR)
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Right colon cancer accounts for 25% of the 42,000 new cases of colorectal cancer diagnosed each year in the UK.
A number of studies have demonstrated worse overall survival in patients with potentially curable right sided colon cancer compared with equivalently staged left colon and rectal cancer.
Surgery is the mainstay of treatment for colon cancer. There is increasing evidence that more extensive surgery, in the form of complete mesocolic excision (CME), may improve outcomes in patients with right colon cancer. CME is however technically complex and potentially associated with increased complications for the patient.
Currently there is no reliable method of stratifying patients in to high and low risk groups at the time of diagnosis to tailor the surgical treatment to the individual.
The TDV CT staging system, based on the depth of tumour invasion (T), presence of tumour deposits (D) and/or extramural venous invasion (V) if validated for assessment of right colon cancer, may provide such a tool.
This study aims to retrospectively review the pre-operative staging CT scans of patients who underwent surgery with curative intent for right colon cancer at the Royal Marsden network of hospitals and St Mark's Hospital to determine the validity of the CT TDV staging system as a prognostic biomarker.
The resulting 'TDV poor' and 'TDV good' prognostic groups will then be assessed against surgical procedure (standard right hemicolectomy versus CME) and colonoscopic tissue biomarkers to determine if this stratification method can provide a means to tailor the surgical technique to the individual to improve the outcomes of patients with right colon cancer.
REC name
HSC REC B
REC reference
20/NI/0179
Date of REC Opinion
15 Dec 2020
REC opinion
Favourable Opinion