DOUBLE-CRT: version 1
Research type
Research Study
Full title
Dual Site Left Endocardial Pacing for Cardiac Resynchronisation Therapy
IRAS ID
154338
Contact name
Heather House
Contact email
Sponsor organisation
Oxford University Hospitals NHS Trust
Clinicaltrials.gov Identifier
Research summary
We are investigating ways to help patients with heart failure, which is caused by damaged hearts which function less well, and cause symptoms of breathlessness, fatigue, lack of energy and swelling.
Cardiac Resynchronisation Therapy (CRT) pacemakers are used to improve the pumping function of the main heart chamber in certain suitable people with heart failure. CRT requires a pacemaker with 2 wires, one placed inside the right heart chamber and one normally placed on the outside of the left heart chamber. These two wires act together to re-time the coordination of the heartbeat, which is known to improve heart function.
We are investigating whether we might be able to improve heart function even more by placing two wires on the inside of the left heart chamber, rather than one around the outside.
We wish to assess the improvement in heart function by using two wires inside the heart. We will do this in patients having an ablation procedure to treat abnormal heart rhythms, as these patients have almost all of the equipment needed for the research already in use for the procedure.REC name
South Central - Oxford C Research Ethics Committee
REC reference
14/SC/1286
Date of REC Opinion
2 Oct 2014
REC opinion
Favourable Opinion