DOME: Sequential analysis of Uterine Artery DOppler MEasurments
Research type
Research Study
Full title
DOME - Sequential analysis of uterine artery Doppler values in high risk population for placenta mediated disease (PMD) undergoing aspirin prophylactic therapy.
IRAS ID
173390
Contact name
Raya Vinogradov
Contact email
Duration of Study in the UK
0 years, 3 months, 17 days
Research summary
This is a pilot retrospective quantitative study will describe changes in uterine arteries blood flow characteristics in high risk patients undergoing prophylactic therapy for placenta mediated disease.
Preeclampsia (PET) and fetal growth restriction (FGR) are closely related to abnormal placental function and classed as placenta mediated diseases (PMD). Despite all prevention attempts PMD remains major contributing factor to maternal and neonatal morbidity and mortality.
PET affects four million women every year worldwide (The Wold Health Report 2005). PET is manifested by high blood pressure and presence of excess protein in urine.
FGR is a condition were fetus is unable to reach its' genetic potential due to abnormal placental function.
The current recommendation is to offer small dose of Aspirin (75 mg) to all high risk pregnancies as prophylactic therapy.
Uterine artery Doppler (UAD) examines placental blood flow and is known to predict PMD.
Assuming Aspirin affects placental blood flow, a single Doppler measurement is unlikely to provide clinicians with as valuable information about risk of development of PMD as multiple measurements.
This study will perform sequential analysis of UAD and compare UAD measurements in first and second trimesters: before and following the commencement of aspirin therapy.
The aim of the study is to evaluate feasibility of this analytical approach and to improve accuracy of screening for PET and FGR.
The study will use data collected for an existing ultrasound data base (Viewpoint). Data collection was conducted under Caldecott approval from NUTH NHS foundation trust.
This project will use pseudonymised data and will not have access to patient identifiable information.
Statistical analysis will be performed using SPSS program and results will be used to obtain MCinRes award and disseminated at professional meetings.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
15/NW/0392
Date of REC Opinion
29 Apr 2015
REC opinion
Favourable Opinion