Does Pancreatic Transplantation Reverse Cardiovascular Damage in DM
Research type
Research Study
Full title
Does Kidney and Pancreatic Transplantation Reverse the Collateral Cardiovascular Damage Caused By Diabetes Mellitus
IRAS ID
172103
Contact name
David van Dellen
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Diabetic renal disease is the most significant cause of end stage renal disease (ESRD) on a global level. Diabetic ESRD patients have the highest death rates of any group of ESRD patients. As a consequence, a large proportion of patients on a waiting list for transplantation die of cardiovascular complications. Simultaneous Pancreas Kidney Transplantation (SPKT) , by inducing insulin independence and replacing renal function, has beneficial effects on microvascular diabetic complications and prolongs life expectancy. There is a need for prospective studies to accurately evaluate the impact of SPKT on cardiac function and myocardial ischaemia. We propose to use novel imaging technology to assess structural changes before and after SPKT. Co incidentally we will measure the circulating levels of biomarkers known to indicate high risk for cardiac events. We will perform cardiopulmonary exercise tests (CPET) in patients before and after SPKT to assess any for changes in cardiac function. Furthermore there is a need to identify robust markers for risk of death on the waiting list. Particularly as patients identified as high risk may benefit from intensive medical management and screening during their pre-operative care.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
15/NW/0899
Date of REC Opinion
18 Jan 2016
REC opinion
Further Information Favourable Opinion