Does antenatal vitamin D alter bone’s later response to vibration?
Research type
Research Study
Full title
Does antenatal vitamin D supplementation influence bone’s postnatal response to mechanical stimulation?
IRAS ID
193227
Contact name
Jaya Sujatha Gopal-Kothandapani
Contact email
Sponsor organisation
Sheffield Childrens NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The aim of this study is to investigate how vitamin D supplementation given to pregnant mothers modifies the response of their children’s bone to mechanical stimulation in the form of whole body vibration (WBV).
This study will compare the acute response of bone to WBV in children whose mothers received vitamin D supplementation during pregnancy versus mothers received placebo as part of the Maternal Vitamin D Osteoporosis Study (MAVIDOS).
The MAVIDOS [Maternal Vitamin D Osteoporosis Study] is a large study conducted 3 years ago in Southampton, Sheffield & Oxford. Results from the MAVIDOS study has shown that pregnant women when administered with higher dose of vitamin D increased the strength of the bones in their infants.
We aim to recruit a minimum of 32 out of 56 children of mothers who participated in the MAVIDOS study in Sheffield. These children will be 4 years of age when they participate in this study. From our previous experience of conducting a similar study in children aged between 9 and 11 years of age, we know that children very well tolerate it.
This study will take place over a period of 8 days involving the participants standing on a LivMD vibrating platform device for 10 minutes on 5 consecutive days along with 2 blood tests at day 1 and day 8 of the study.
Participants will also be asked questions about their physical activities 7 days before and during the study visit. Study visits will take place in the child’s home or at school and will last approximately 20-45 minutes during each study visit.
The outcome of this study will help the doctors to identify early children at risk of developing weak bones and look at ways of prevention of osteoporosis in later life. This will also help inform public health policy on vitamin D intake during pregnancy.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
16/YH/0009
Date of REC Opinion
16 Mar 2016
REC opinion
Further Information Favourable Opinion