Does a central venous line reduce perioperative fluid administration?
Research type
Research Study
Full title
In high risk patients undergoing elective colorectal resection, does routine placement of a central venous catheter reduce peri-operative fluid administration in theatre and the critical care unit?
IRAS ID
252375
Contact name
Benjamin Milne
Contact email
Sponsor organisation
Barts Health NHS Trust
Clinicaltrials.gov Identifier
252375, IRAS Number
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Some practicing anaesthetists will routinely place central lines in patients deemed high risk (predicted mortality >5%/requiring critical care bed post-operatively), and others will not. Enhanced recovery studies and more recent trials have shown conflicting results in regards to whether restrictive or liberal fluid regimens in these patients is beneficial. We seek to investigate whether insertion of a central venous catheter at the start of surgery influences perioperative fluid volumes and vasopressor use.
Perceived benefits of placing a central line are of measuring central venous pressure, the ability to administer drugs in smaller volumes, administer multiple drugs at one time, the ability to use a noradrenaline infusion to support blood pressure, and repeatedly measure the oxygen saturation of the blood via the central veins as a measure of oxygen delivery to the tissues. These are contentious however, and most enhanced recovery protocols would advocate the avoidance of indwelling, invasive vascular access.
The study aims to assess whether the placement of a central line in these patients does result in smaller volumes of fluid being administered during their peri-operative journey.
REC name
London - Central Research Ethics Committee
REC reference
19/LO/0099
Date of REC Opinion
8 Mar 2019
REC opinion
Further Information Favourable Opinion